Vinpocetine Tablets

Mechanism

Vinpocetine inhibits phosphodiesterase type 1 (PDE1), increases cyclic GMP, and enhances cerebral vasodi lation. It improves neuronal metabolism, reduces platelet aggregation, and protects against ischemic damage.

Pharmacokinetics

• Absorption: Rapidly absorbed after oral administration.
• Peak Plasma Concentration: 1–2 hours post-dose.
• Protein Binding: ~66% bound to plasma proteins.
• Metabolism: Extensively metabolized in the liver.
• Excretion: Primarily via urine and feces.
• Half-life: ~4–5 hours.

Side Effects

• Headache
• Dizziness
• Gastrointestinal upset
• Rare: Hypotension, flushing

Contraindication

• Pregnancy and breastfeeding
• Severe cardiac arrhythmias
• Hypersensitivity to Vinpocetine

Interaction

• Anticoagulants (may increase bleeding risk)
• Antihypertensives (additive hypotensive effect)

Warning and Precautions

• Use under medical supervision only
• Monitor blood pressure regularly
• Caution in elderly patients