Valsartan + Amlodipine + Hydrochlorothiazide Tablets

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Therapeutic Indication

Hypertension (high blood pressure)
Cardiovascular disease prevention
Patients requiring triple therapy for BP control
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Valsartan + Amlodipine + Hydrochlorothiazide

Tablet

This combination medicine lowers blood pressure through three mechanisms: Valsartan blocks angiotensin II receptors, Amlodipine relaxes blood vessels, and Hydrochlorothiazide promotes diuresis. It is prescribed for patients with resistant hypertension to reduce the risk of stroke, heart attack, and kidney damage.

Speciality Cardiology | Internal Medicine
Tags Cardiac Care | Hypertension Control | Triple Therapy
Strength
  • Valsartan 80 mg
  • Amlodipine 5 mg
  • Hydrochlorothiazide 12.5 mg
Packing Size
  • 10 Tablets

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Mechanism

Valsartan blocks angiotensin II receptors, preventing vasoconstriction. Amlodipine, a calcium channel blocker, relaxes vascular smooth muscle. Hydrochlorothiazide increases urinary excretion of sodium and water, reducing blood volume. Together, they provide powerful antihypertensive control.

Pharmacokinetics

  • Absorption: Well absorbed orally
  • Distribution: Protein-bound
  • Metabolism: Valsartan minimal hepatic metabolism; Amlodipine hepatic metabolism; Hydrochlorothiazide minimally metabolized
  • Elimination: Renal excretion
  • Half-life: Valsartan ~6 hrs, Amlodipine ~30-50 hrs, Hydrochlorothiazide ~6-15 hrs

Side Effects

  • Dizziness
  • Fatigue
  • Peripheral edema (from Amlodipine)
  • Electrolyte imbalance (low potassium, sodium)
  • Hypotension

Contraindication

    li>Severe kidney disease
  • Pregnancy and breastfeeding
  • Hypersensitivity to sulfonamides
  • Children under 18 years

Interaction

  • Other antihypertensives (risk of hypotension)
  • NSAIDs (reduced efficacy, kidney risk)
  • Potassium supplements or sparing diuretics (risk of hyperkalemia)
  • Alcohol (enhanced BP lowering effect)

Warning and Precautions

  • Monitor blood pressure regularly
  • Check electrolytes (potassium, sodium)
  • Use with caution in elderly patients
  • Avoid dehydration during therapy

Dosage

As directed by the Physician.