Trioxsalen Tablets

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Therapeutic Indication

Vitiligo (PUVA therapy)
Psoriasis
Certain eczema cases
Other photochemotherapy indications
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Trioxsalen

Tablet

Trioxsalen is a psoralen derivative used in PUVA therapy. It sensitizes the skin to UVA light, promoting repigmentation in vitiligo and reducing lesions in psoriasis.

Speciality Dermatology | Phototherapy
Tags Vitiligo | Psoriasis | PUVA Therapy | Photochemotherapy
Strength
  • 25 mg
Packing Size
  • 10 Tablets

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Mechanism

Trioxsalen intercalates into DNA and, upon UVA exposure, forms cross-links that modify cell replication. This helps restore pigmentation in vitiligo and reduces hyperproliferation in psoriasis.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally.
  • Metabolism: Metabolized in liver.
  • Excretion: Primarily via urine.
  • Half-life: ~2–4 hours.

Side Effects

  • Nausea
  • Itching
  • Skin redness
  • Blistering (with excessive UVA exposure)
  • Long-term risk: Skin aging, skin cancer

Contraindication

  • Hypersensitivity to psoralens
  • Pregnancy
  • Porphyria
  • History of skin cancer

Interaction

  • Other photosensitizing drugs (tetracyclines, sulfonamides)
  • Alcohol (increases liver stress)

Warning and Precautions

  • Strict UVA exposure control required
  • Monitor skin regularly for malignancy
  • Use protective eyewear during therapy

Dosage

As directed by the Physician.