Trimetazidine Tablets

Mechanism

• Shifts myocardial energy metabolism from fatty acid oxidation to glucose oxidation.
• Improves efficiency of ATP production in ischemic conditions.
• Reduces angina frequency and improves exercise tolerance.

Pharmacokinetics

• Absorption: Rapidly absorbed after oral administration.
• Distribution: Widely distributed, moderate protein binding.
• Metabolism: Minimal hepatic metabolism.
• Excretion: Primarily via urine (renal clearance).

Side Effects

• Nausea, vomiting
• Dizziness
• Abdominal pain
• Rare extrapyramidal symptoms

Contraindication

• Hypersensitivity to trimetazidine
• Parkinson’s disease or movement disorders
• Severe renal impairment

Interaction

• Generally safe with other cardiovascular drugs.
• Use with caution in patients on nephrotoxic agents.

Warning and Precautions

• Not recommended as first-line therapy for angina.
• Monitor renal function during long-term use.
• Discontinue if movement disorders occur.

Dosage

As directed by the Physician.