Tranexamic Acid + Etamsylate Tablets

Therapeutic Indication

Heavy menstrual bleeding (menorrhagia)

Surgical bleeding

Capillary fragility

Adjunct therapy in gynecological bleeding/td>

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Tranexamic Acid + Etamsylate

Tablet

This fixed-dose combination provides dual hemostatic action. Tranexamic Acid, an antifibrinolytic, prevents breakdown of blood clots, while Etamsylate enhances platelet adhesion and capillary resistance. Together, they reduce excessive bleeding in gynecological, surgical, and capillary fragility conditions.

Speciality	Gynecology \| Hematology \| Surgery
Tags	Antifibrinolytic \| Hemostatic Agent \| Menorrhagia \| Surgical Bleeding \| Combination Therapy
Strength	Tranexamic Acid 250 mg Etamsylate 250 mg
Packing Size	10 Tablets

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Mechanism

Tranexamic Acid: Competitively inhibits plasminogen activation → prevents fibrin degradation → stabilizes blood clots.
Etamsylate: Enhances platelet adhesion and capillary resistance → reduces capillary bleeding.

Pharmacokinetics

Tranexamic Acid Absorption: Rapidly absorbed orally; peak plasma levels in 3 hrs.
Etamsylate Absorption: Rapidly absorbed orally; peak plasma levels in 1–2 hrs.
Distribution: Tranexamic Acid widely distributed; Etamsylate concentrates in capillaries.
Metabolism: Tranexamic Acid minimally metabolized; Etamsylate metabolized hepatically.
Excretion: Tranexamic Acid via urine; Etamsylate via urine and bile.
Half-life: Tranexamic Acid ~2–3 hrs; Etamsylate ~8 hrs.

Side Effects

Nausea, vomiting
Dizziness
Hypotension (rare)
Allergic reactions (rare)

Contraindication

Active thromboembolic disease
Hypersensitivity to Tranexamic Acid or Etamsylate
Severe renal impairment

Interaction

Anticoagulants (warfarin, heparin) may reduce efficacy
Hormonal contraceptives ↑ risk of thrombosis
Other antifibrinolytics may potentiate effect

Warning and Precautions

Monitor coagulation profile in long-term use
Use cautiously in patients with thromboembolic risk
Discontinue if allergic reaction occurs

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Please consult a healthcare professional before using any medicinal product.