Tinidazole Tablets

Therapeutic Indication

Amoebiasis (intestinal and hepatic)

Giardiasis

Trichomoniasis

Anaerobic bacterial infections

Prophylaxis in surgical infections

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Tinidazole

Tablet

Tinidazole is a nitroimidazole derivative with antiprotozoal and antibacterial properties. It is effective against protozoa such as *Entamoeba histolytica*, *Giardia lamblia*, and *Trichomonas vaginalis*, as well as anaerobic bacteria. Tinidazole is widely prescribed for intestinal and systemic protozoal infections and anaerobic bacterial conditions.

Speciality	Antiprotozoal / Antibacterial/td>
Tags	Amoebiasis \| Giardiasis \| Trichomoniasis \| Anaerobic Infections
Strength	400 mg
Packing Size	10 Tablets

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Mechanism

Tinidazole enters protozoal and bacterial cells, where its nitro group is reduced by intracellular transport proteins. The resulting reactive intermediates damage DNA and other critical biomolecules, leading to cell death.

Pharmacokinetics

Absorption: Rapid oral absorption, bioavailability ≈ 100%
Distribution: Widely distributed, crosses placenta and enters breast milk
Metabolism: Hepatic metabolism via oxidation and conjugation
Elimination: Renal and fecal excretion
Half-life: ≈ 12–14 hours

Side Effects

Nausea and vomiting
Metallic taste
Abdominal discomfort
Dizziness
Rare: peripheral neuropathy

Contraindication

First trimester of pregnancy
Hypersensitivity to nitroimidazoles
Neurological disorders (use cautiously)

Interaction

Alcohol — disulfiram-like reaction (avoid during and 72 hours after therapy)
Warfarin — enhances anticoagulant effect
CYP3A4 inducers (rifampicin, phenytoin) — reduce plasma levels
CYP3A4 inhibitors (ketoconazole) — increase plasma levels

Warning and Precautions

Avoid alcohol during and after therapy
Monitor liver function in prolonged use
Use cautiously in patients with CNS disease