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Tamsulosin + Dutasteride Tablets

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Therapeutic Indication

Benign prostatic hyperplasia (BPH)
Improvement of urinary flow
Reduction of prostate size
Relief of lower urinary tract symptoms (LUTS)
Prevention of acute urinary retention
Reduction in need for prostate surgery
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Tamsulosin + Dutasteride

Tablet

This combination therapy provides dual action for BPH management. Tamsulosin improves urinary flow by relaxing smooth muscle in the prostate and bladder neck, while Dutasteride reduces prostate size by inhibiting the conversion of testosterone to dihydrotestosterone (DHT).

Speciality Urology | BPH Management
Tags BPH | Prostate Health | LUTS | Urinary Flow
Strength
  • Tamsulosin 0.4 mg
  • Dutasteride 0.5 mg
Packing Size
  • 10 Tablets

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Mechanism

Dutasteride blocks the action of an enzyme called 5-alpha-reductase. This enzyme changes testosterone to another hormone that causes the prostate gland to grow. Dutasteride will cause the size of the prostate to decrease, but the effect lasts only as long as the medicine is taken. If it is stopped, the prostate begins to grow again. Tamsulosin helps relax the muscles in the prostate gland and the opening of the bladder. This may help increase the flow of urine or decrease symptoms.

Pharmacokinetics

  • Absorption: Tamsulosin is well absorbed orally; Dutasteride has high oral bioavailability.
  • Distribution: Both drugs are highly protein bound.
  • Metabolism: Tamsulosin via CYP3A4/CYP2D6; Dutasteride via CYP3A4.
  • Elimination: Tamsulosin via urine/feces; Dutasteride mainly via feces.
  • Half-life: Tamsulosin ≈ 9–13 hours; Dutasteride ≈ 5 weeks.

Side Effects

  • Dizziness
  • Orthostatic hypotension
  • Decreased libido
  • Ejaculation disorders
  • Gynecomastia
  • Rare: allergic reactions

Contraindication

  • Hypersensitivity to Tamsulosin, Dutasteride, or excipients
  • Severe hepatic impairment
  • Women and children — contraindicated

Interaction

  • CYP3A4 inhibitors: Increase levels of both drugs (e.g., ketoconazole).
  • Antihypertensives: Additive hypotensive effect with Tamsulosin.
  • PDE‑5 inhibitors: Risk of severe hypotension.
  • Warfarin: Monitor INR when co‑administered.

Warning and Precautions

  • Monitor blood pressure regularly.
  • Advise patients to rise slowly from sitting/lying positions.
  • Women who are pregnant should not handle crushed/broken tablets.
  • Monitor liver function during therapy.