Tadalafil + Dapoxetine Tablets

Therapeutic Indication

Erectile dysfunction

Premature ejaculation

Zinc Sulphate

Tablet

This combination therapy is used to manage erectile dysfunction and premature ejaculation. Tadalafil improves penile blood flow by inhibiting PDE5, while Dapoxetine, a short-acting SSRI, delays ejaculation by increasing serotonin activity.

Speciality	Urology \| Sexual Medicine
Tags	ED Treatment \| Premature Ejaculation \| Sexual Health
Strength	Tadalafil 10 mg + Dapoxetine 30 mg Tadalafil 20 mg + Dapoxetine 60 mg
Packing Size	10 Tablets

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Mechanism

Tadalafil inhibits PDE5, enhancing nitric oxide–mediated vasodilation in penile tissue. Dapoxetine increases serotonin levels in the synaptic cleft, delaying ejaculation reflex.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Tadalafil highly protein-bound; Dapoxetine widely distributed.
Metabolism: Hepatic metabolism via CYP enzymes.
Elimination: Renal and fecal excretion.
Half-life: Tadalafil ~17.5 hours; Dapoxetine ~1.5 hours.

Side Effects

Headache
Dizziness
Nausea
Flushing
Insomnia

Contraindication

Severe cardiac disease
Concurrent nitrate therapy
Hypersensitivity to ingredients

Interaction

Nitrates (risk of severe hypotension)
Other SSRIs or MAO inhibitors (risk of serotonin syndrome)

Warning and Precautions

Use cautiously in patients with cardiovascular disease
Avoid alcohol (may worsen side effects)
Not recommended for patients under 18 years

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.