Sulfadoxine + Pyrimethamine Tablets

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Therapeutic Indication

Treatment of malaria (including chloroquine-resistant strains)
Intermittent preventive treatment in pregnancy (IPTp)
Prophylaxis in high-risk endemic areas
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Sulfadoxine + Pyrimethamine

Tablet

Sulfadoxine–Pyrimethamine is a fixed-dose antimalarial combination. It acts synergistically by inhibiting folate synthesis and DNA replication in Plasmodium parasites, making it effective against resistant strains.

Speciality Infectious Diseases | General Medicine | Obstetrics
Tags Antimalarial | Malaria | IPTp
Strength
  • Sulfadoxine 500 mg
  • Pyrimethamine 25 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Sulfadoxine inhibits dihydropteroate synthase (DHPS), blocking folate synthesis. Pyrimethamine inhibits dihydrofolate reductase (DHFR), preventing DNA synthesis. Together, they halt parasite growth and replication.

Pharmacokinetics

  • Absorption: Well absorbed orally; peak plasma levels in 4–8 hours.
  • Distribution: Widely distributed; crosses placenta.
  • Metabolism: Hepatic metabolism.
  • Elimination: Renal excretion.
  • Half-life: Sulfadoxine ~7–9 days; Pyrimethamine ~3–5 days.

Side Effects

  • Nausea, vomiting, diarrhea
  • Dizziness, headache
  • Skin rash, mouth sores
  • Rare: severe allergic reactions, anemia, jaundice, seizures

Contraindication

  • Hypersensitivity to sulfa drugs
  • Severe liver/kidney impairment
  • Megaloblastic anemia due to folate deficiency
  • Use in first trimester of pregnancy

Interaction

  • Other antifolate drugs (additive toxicity)
  • Alcohol (worsens side effects)
  • Phenytoin (increased toxicity)

Warning and Precautions

  • Complete full course; do not skip doses
  • Use cautiously in pregnancy

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.