Spironolactone Tablets

Therapeutic Indication

Hypertension (as adjunct therapy)

Congestive heart failure (reduces morbidity and mortality)

Edema due to cirrhosis, nephrotic syndrome, or CHF

Primary hyperaldosteronism

Hypokalemia prevention in patients on diuretics

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Spironolactone

Tablet

Spironolactone is a potassium-sparing diuretic and aldosterone antagonist. It reduces sodium and water retention while conserving potassium, making it effective in hypertension, heart failure, edema, and hyperaldosteronism.

Speciality	Cardiology \| Nephrology \| Endocrinology
Tags	Hypertension \| Heart Failure \| Diuretic \| Aldosterone Antagonist
Strength	25 mg 50 mg 100 mg
Packing Size	10 Tablets

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Mechanism

Spironolactone competitively inhibits aldosterone at mineralocorticoid receptors in the distal renal tubules. This reduces sodium reabsorption and water retention while conserving potassium. It also has anti-androgenic effects by blocking androgen receptors and inhibiting testosterone synthesis.

Pharmacokinetics

Side Effects

Nausea
Hyperkalemia
Gynecomastia
Menstrual irregularities
GI upset (nausea, vomiting, diarrhea)
Drowsiness

Contraindication

Hyperkalemia
Severe renal impairment
Addison’s disease
Hypersensitivity to Spironolactone

Interaction

ACE inhibitors/ARBs: ↑ risk of hyperkalemia
Potassium supplements: ↑ serum potassium
NSAIDs: ↓ diuretic effect, ↑ risk of renal impairment
Digoxin: may alter digoxin clearance

Warning and Precautions

Monitor serum potassium and renal function regularly
Use caution in elderly patients
Risk of gynecomastia and endocrine side effects with long-term use
Adjust dose in hepatic impairment

Dosage

As directed by the Physician.