Spironolactone + Frusemide Tablets

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Therapeutic Indication

Edema due to congestive heart failure
Hypertension (as adjunct therapy)
Ascites due to liver cirrhosis
Nephrotic syndrome
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Spironolactone + Frusemide

Tablet

This fixed-dose combination provides effective diuretic therapy. Spironolactone is a potassium-sparing diuretic, while Frusemide is a loop diuretic. Together, they reduce fluid overload while minimizing potassium loss.

Speciality Cardiology | Nephrology | Endocrinology
Tags Diuretic | Heart Failure | Hypertension | Edema
Strength
  • Spironolactone 50 mg
  • Frusemide 20 mg
Packing Size
  • 10 Tablets

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Mechanism

Spironolactone: Aldosterone antagonist, reduces sodium reabsorption and conserves potassium.
Frusemide: Inhibits sodium-potassium-chloride transporter in the loop of Henle, producing potent diuresis.

Pharmacokinetics

  • Spironolactone: Absorbed orally; metabolized in liver to active metabolites; half-life ~1.5 hours (metabolites longer); excreted via urine and bile.
  • Frusemide: Rapid absorption; peak plasma concentration in 1–2 hours; half-life ~1–2 hours; excreted unchanged in urine.

Side Effects

  • Hyperkalemia (due to Spironolactone)
  • Hypokalemia, dehydration (due to Frusemide)
  • Dizziness, hypotension
  • Gynecomastia (Spironolactone)

Contraindication

  • Severe renal impairment
  • Anuria
  • Hyperkalemia
  • Hypersensitivity to either drug

Interaction

  • ACE inhibitors/ARBs (increase risk of hyperkalemia)
  • NSAIDs (reduce diuretic efficacy)
  • Digoxin (risk of toxicity with electrolyte imbalance)

Warning and Precautions

  • Use under medical supervision only
  • Monitor electrolytes regularly
  • Caution in elderly patients
  • Avoid potassium supplements unless prescribed

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.