Sparfloxacin Tablets

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Therapeutic Indication

Respiratory tract infections (bronchitis, pneumonia)
Urinary tract infections
Skin and soft tissue infections
ENT infections
Prostatitis
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Sparfloxacin

Tablet

Sparfloxacin is a broad-spectrum fluoroquinolone antibiotic. It is effective against Gram-positive and Gram-negative bacteria, making it useful in respiratory, urinary, and skin infections. Its long half-life allows once-daily dosing.

Speciality Infectious Diseases | Pulmonology | Urology | Dermatology
Tags Fluoroquinolone | Antibiotic | Respiratory Infections | UTI
Strength
  • 200 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Sparfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to bacterial cell death and effective infection control.

Pharmacokinetics

  • Absorption: Rapid oral absorption; bioavailability ~90%.
  • Distribution: Widely distributed in tissues.
  • Metabolism: Limited hepatic metabolism.
  • Elimination: Excreted in urine and feces.
  • Half-life: ~16–20 hours (supports once-daily dosing).

Side Effects

  • Nausea, vomiting, diarrhea
  • Dizziness, headache
  • Photosensitivity (sunburn risk)
  • QT prolongation (rare but serious)

Contraindication

  • Hypersensitivity to fluoroquinolones
  • Pregnancy and lactation
  • Children and adolescents (risk of cartilage damage)
  • Patients with known QT prolongation

Interaction

  • Antacids containing Mg/Al: Reduce absorption.
  • Antiarrhythmic drugs: Increased risk of QT prolongation.
  • Warfarin: May enhance anticoagulant effect.

Warning and Precautions

  • Avoid excessive sunlight exposure due to photosensitivity.
  • Monitor ECG in patients at risk of QT prolongation.
  • Adjust dose in renal impairment.
  • Discontinue if tendon pain or inflammation occurs.

Dosage

As directed by the Physician.