Therapeutic Indication
| Epilepsy (generalized and partial seizures) |
| Bipolar disorder (mania prophylaxis) |
| Migraine prophylaxis |
| Adjunct in psychiatric disorders |
Sodium Valproate + Valproic Acid
Tablet
A broad-spectrum anticonvulsant formulation combining sodium valproate and valproic acid to stabilize neuronal activity, treat epilepsy, bipolar disorder, and prevent migraines.
| Speciality | Neurology | Psychiatry | Internal Medicine |
|---|---|
| Tags | Epilepsy | Bipolar Disorder | Migraine | Anticonvulsant |
| Strength |
|
| Packing | 10 Tablets |
Mechanism
- Increases GABA levels in the brain, enhancing inhibitory neurotransmission.
- Stabilizes neuronal membranes and reduces excitatory impulses.
- Prevents abnormal electrical activity responsible for seizures and mood swings.
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration.
- Distribution: Widely distributed, highly protein bound.
- Metabolism: Extensively metabolized in liver via glucuronidation and β-oxidation.
- Excretion: Primarily via urine as metabolites.
Side Effects
- Nausea, vomiting, abdominal pain
- Weight gain
- Tremor, dizziness
- Hair loss (alopecia)
- Rare hepatotoxicity and pancreatitis
Contraindication
- Hypersensitivity to valproate
- Hepatic impairment
- Pregnancy (risk of teratogenicity)
Interaction
- May increase levels of lamotrigine, carbamazepine, and phenytoin.
- Alcohol and CNS depressants enhance sedative effects.
- Aspirin may increase valproate levels.
Warning & Precautions
- Monitor liver function tests regularly.
- Use with caution in children under 2 years.
- Gradual dose titration recommended to minimize side effects.
Dosage
As directed by the Physician.