Sertraline Tablets

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Therapeutic Indication

Major depressive disorder
Anxiety disorders
Obsessive-compulsive disorder (OCD)
Post-traumatic stress disorder (PTSD)
Panic disorder
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Sertraline

Tablet

Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin levels in the brain, improving mood, reducing anxiety, and alleviating symptoms of depression, OCD, and PTSD.

Speciality Psychiatry | Neurology
Tags Antidepressant | SSRI | Anxiety Relief
Strength
  • 25 mg
Packing Size
  • 10 Tablets

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Mechanism

Sertraline selectively inhibits serotonin reuptake in the presynaptic neuron, increasing serotonin availability in the synaptic cleft, which enhances mood and reduces anxiety.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Distribution: Highly protein-bound.
  • Metabolism: Hepatic metabolism via CYP enzymes.
  • Elimination: Renal and fecal excretion.
  • Half-life: ~26 hours.

Side Effects

  • Nausea
  • Insomnia
  • Sexual dysfunction
  • Dry mouth
  • Drowsiness

Contraindication

  • Concurrent use with MAO inhibitors
  • Hypersensitivity to sertraline

Interaction

  • MAO inhibitors : Phenelzine, tranylcypromine, Other serotonergic drugs
  • Triptans, tramadol, linezolid, lithium, Antiplatelets/anticoagulants
  • Aspirin, warfarin, clopidogrel, CYP2D6 substrates
  • Metoprolol, tamoxifen, Alcohol & CNS depressants
  • Ethanol, benzodiazepines, St. John’s Wort
  • Herbal antidepressant

Warning and Precautions

  • Sertraline should not be used concomitantly with MAO inhibitors or pimozide due to risk of serious interactions
  • Monitor patients for signs of suicidality, especially during initiation and dose changes
  • Concomitant use with serotonergic agents increases risk of serotonin syndrome; discontinue if symptoms occur.
  • Use with caution in patients with hepatic impairment; dose adjustment may be required
  • Abrupt discontinuation may cause withdrawal symptoms; taper gradually under medical supervision.

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.