Roxithromycin Tablets

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Therapeutic Indication

Respiratory tract infections (bronchitis, pneumonia)
Urinary tract infections
Skin and soft tissue infections
ENT infections (pharyngitis, tonsillitis, sinusitis)
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Roxithromycin

Tablet

Roxithromycin is a semi-synthetic macrolide antibiotic used in the treatment of respiratory, urinary, skin, and ENT infections. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing bacterial growth.

Speciality Infectious Diseases | Pulmonology | Dermatology | General Medicine
Tags Macrolide Antibiotic | Respiratory Infections | Skin Infections
Strength
  • 150 mg
  • 300 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Roxithromycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting translocation steps in protein synthesis. This action prevents bacterial growth and replication.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration; peak plasma concentration in 1–2 hours.
  • Bioavailability: ~50%.
  • Distribution: Widely distributed; high concentrations in lungs and tonsils.
  • Metabolism: Partially metabolized in the liver.
  • Excretion: Primarily excreted unchanged in bile and feces; minor renal excretion.
  • Half-life: ~12 hours, supporting twice-daily dosing.

Side Effects

  • Nausea
  • Abdominal pain
  • Diarrhea
  • Skin rash
  • Headache

Contraindication

  • Hypersensitivity to macrolides
  • Severe hepatic impairment

Interaction

  • Warfarin (may enhance anticoagulant effect)
  • Theophylline (increased plasma levels)
  • Other macrolides (additive effect)

Warning and Precautions

  • Use under medical supervision only
  • Caution in patients with liver disease
  • Monitor for allergic reactions

Dosage

As directed by the Physician.