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Therapeutic Indication

Acute treatment of migraine attacks with or without aura

Rapid relief of migraine-associated symptoms (headache, nausea, photophobia, phonophobia)

Not indicated for prophylaxis of migraine or cluster headaches

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Rizatriptan

Tablet

Rizatriptan is a selective serotonin 5-HT1B/1D receptor agonist used for the acute treatment of migraine attacks. It works by constricting intracranial blood vessels and inhibiting neuropeptide release, thereby relieving migraine pain and associated symptoms.

Speciality	Neurology \| Pain Management
Tags	Migraine \| Triptan \| Neurology
Strength	10 mg
Packing Size	10 Tablets

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Mechanism

Rizatriptan binds selectively to serotonin 5-HT1B and 5-HT1D receptors, causing vasoconstriction of dilated cranial blood vessels and inhibiting release of pro-inflammatory neuropeptides. This dual action alleviates migraine pain and associated symptoms.

Pharmacokinetics

Bioavailability: ~40–45%
Peak plasma concentration: 1–1.5 hours
Half-life: ~2–3 hours
Metabolism: Hepatic via monoamine oxidase-A (MAO-A)
Excretion: Primarily via urine

Side Effects

Dizziness
Fatigue
Somnolence
Chest discomfort
Rare: myocardial ischemia, arrhythmia

Contraindication

Hypersensitivity to Rizatriptan
History of ischemic heart disease, stroke, or uncontrolled hypertension
Concomitant use with MAO inhibitors
Use within 24 hours of another triptan or ergotamine derivative

Interaction

MAO-A inhibitors: ↑ plasma levels of Rizatriptan
Propranolol: ↑ Rizatriptan concentration, dose adjustment required
Other triptans/ergot derivatives: ↑ risk of vasospasm

Warning and Precautions

Assess cardiovascular status before prescribing
Not recommended in patients with uncontrolled hypertension
Use caution in hepatic impairment
Discontinue if chest pain or ischemic symptoms occur

Dosage

As directed by the Physician.

Rizatriptan Tablets