Ritonavir Tablets

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Therapeutic Indication

HIV-1 infection (in combination therapy)
Pharmacokinetic booster for other protease inhibitors
Long-term HIV management and viral suppression
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Ritonavir

Tablet

Ritonavir is an antiretroviral medication belonging to the protease inhibitor class. It is primarily used as a booster to enhance the plasma levels of other protease inhibitors, improving their efficacy in HIV treatment. Ritonavir plays a critical role in combination therapy for long-term HIV management.

Speciality Protease Inhibitor / Antiretroviral Booster
Tags HIV | Antiretroviral | Protease Inhibitor | Booster Therapy
Strength
  • 100 mg
Packing Size
  • 10 0r 30 need to confirm Tablets

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Mechanism

Ritonavir inhibits HIV protease, preventing viral replication. It also strongly inhibits CYP3A4 enzymes, slowing the metabolism of other protease inhibitors and boosting their plasma concentration.

Pharmacokinetics

  • Absorption: Enhanced with food
  • Distribution: Widely distributed
  • Metabolism: Hepatic via CYP3A4 and CYP2D6
  • Elimination: Primarily fecal
  • Half-life: 3–5 hours

Side Effects

  • Nausea and diarrhea
  • Abdominal pain
  • Liver toxicity
  • Lipid abnormalities

Contraindication

  • Severe hepatic impairment
  • Hypersensitivity to Ritonavir

Interaction

  • Strong CYP3A4 inhibition — interacts with antibiotics, antifungals, statins, anticoagulants
  • Requires careful monitoring with other antiretrovirals

Warning and Precautions

  • Monitor liver function regularly
  • Check lipid profile during therapy
  • Use cautiously with multiple drug regimens