Risperidone + Trihexyphenidyl Tablets

Therapeutic Indication

Schizophrenia

Psychotic disorders

Drug-induced extrapyramidal symptoms (EPS)

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Risperidone + Trihexyphenidyl

Tablet

Risperidone is an atypical antipsychotic that balances dopamine and serotonin activity to treat schizophrenia and other psychotic disorders. Trihexyphenidyl is an anticholinergic agent used to prevent or reduce extrapyramidal side effects caused by antipsychotic therapy.

Speciality	Psychiatry \| Neurology \| Internal Medicine
Tags	Antipsychotic \| Anticholinergic \| Schizophrenia Treatment \| EPS Management
Strength	Risperidone 3 mg + Trihexyphenidyl 2 mg Risperidone 4 mg + Trihexyphenidyl 2 mg
Packing Size	10 Tablets

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Mechanism

Risperidone blocks dopamine D2 and serotonin 5-HT2 receptors, reducing psychotic symptoms. Trihexyphenidyl blocks central cholinergic receptors, preventing extrapyramidal side effects.

Pharmacokinetics

Absorption: Risperidone well absorbed orally; Trihexyphenidyl rapidly absorbed.
Metabolism: Risperidone metabolized hepatically via CYP2D6; Trihexyphenidyl metabolized in liver.
Excretion: Risperidone via urine; Trihexyphenidyl via urine and feces.
Half-life: Risperidone ~20 hours; Trihexyphenidyl ~3–4 hours.

Side Effects

Drowsiness
Weight gain
Dry mouth
Blurred vision
Constipation
Rare: Tardive dyskinesia, Neuroleptic Malignant Syndrome

Contraindication

Hypersensitivity to risperidone or trihexyphenidyl
Angle-closure glaucoma
Severe hepatic impairment

Interaction

Other CNS depressants (additive sedation)
Antihypertensives (enhanced hypotension)
Anticholinergics (additive side effects)

Warning and Precautions

Monitor for metabolic changes (weight, glucose, lipids)
Use cautiously in elderly patients
Discontinue if severe EPS or tardive dyskinesia occurs
Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.