Rifampicin + Isoniazid Tablets

Therapeutic Indication

Active pulmonary tuberculosis

Extrapulmonary tuberculosis

Latent TB (preventive therapy, in combination regimens)

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Rifampicin + Isoniazid

Tablet

This fixed-dose combination is a cornerstone of first-line anti-tuberculosis therapy. Rifampicin and Isoniazid together provide potent bactericidal activity, preventing resistance and improving treatment outcomes.

Speciality	Infectious Diseases \| Pulmonology \| Internal Medicine
Tags	Anti-TB \| Combination Therapy \| Rifampicin \| Isoniazid \| Tuberculosis
Strength	Rifampicin 450 mg Isoniazid 300 mg
Packing Size	10 Tablets

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Mechanism

Rifampicin: Inhibits DNA-dependent RNA polymerase in mycobacteria → blocks RNA synthesis → bactericidal.
Isoniazid: Inhibits synthesis of mycolic acids, essential components of mycobacterial cell wall → bactericidal.

Side Effects

Hepatotoxicity (elevated liver enzymes, jaundice)
Peripheral neuropathy (Isoniazid, preventable with pyridoxine)
Red-orange discoloration of urine, sweat, tears (Rifampicin)
Gastrointestinal upset
Rare: hypersensitivity reactions

Contraindication

Severe hepatic disease
Hypersensitivity to Rifampicin or Isoniazid

Interaction

Rifampicin induces CYP450 enzymes → reduces efficacy of oral contraceptives, warfarin, antiretrovirals
Isoniazid increases levels of phenytoin and carbamazepine
Alcohol increases hepatotoxicity risk

Warning and Precautions

Monitor liver function regularly
Supplement with pyridoxine (Vitamin B6) to prevent neuropathy
Educate patients about harmless red-orange discoloration of body fluids
Never use as monotherapy for active TB

Dosage

As directed by the Physician.

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As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.