Ramipril + Losartan Tablets

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Therapeutic Indication

Hypertension (high blood pressure)
Cardiovascular risk reduction
Heart failure management
Kidney protection in diabetic nephropathy
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Ramipril + Losartan

Tablet

Combination medicine used to treat hypertension and reduce cardiovascular risks. Ramipril is an ACE inhibitor, while Losartan is an angiotensin receptor blocker (ARB). Together, they provide dual blockade of the renin-angiotensin system.

Speciality Cardiology | Nephrology | General Medicine
Tags Antihypertensive | ACE Inhibitor | ARB
Strength
  • Ramipril 5 mg
  • Losartan 50 mg
Packing Size
  • 10 Tablets

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Mechanism

Ramipril inhibits angiotensin-converting enzyme, reducing angiotensin II formation and relaxing blood vessels. Losartan blocks angiotensin II receptors, preventing vasoconstriction and aldosterone release. Together, they lower blood pressure and protect the heart and kidneys.

Pharmacokinetics

  • Absorption: Rapid oral absorption.
  • Distribution: Wide tissue penetration.
  • Metabolism: Ramipril metabolized in liver to ramiprilat; Losartan metabolized to active metabolite (EXP3174).
  • Elimination: Renal and biliary excretion.
  • Half-life: Ramiprilat ~13–17 hrs; Losartan metabolite ~6–9 hrs.

Side Effects

  • Dizziness, headache
  • Cough (ACE inhibitor effect)
  • Fatigue
  • Electrolyte imbalance (hyperkalemia)
  • Rare: angioedema, kidney dysfunction

Contraindication

  • Pregnancy and lactation
  • Severe renal impairment
  • History of angioedema
  • Concomitant use with aliskiren in diabetic nephropathy

Interaction

  • NSAIDs (reduce effect, increase kidney risk)
  • Potassium supplements/diuretics (risk of hyperkalemia)
  • Lithium (toxicity risk)
  • Alcohol (enhances hypotension)

Warning and Precautions

  • Monitor blood pressure, kidney function, and electrolytes regularly
  • Avoid abrupt discontinuation
  • Use cautiously in elderly patients

Dosage

As directed by the Physician.

Disclaimer

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As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.