Ramipril + Hydrochlorothiazide Tablets

Therapeutic Indication

Hypertension (blood pressure management)

Adjunct therapy in patients uncontrolled on monotherapy

Cardiovascular risk reduction

+91 85919 78885

Ramipril + Hydrochlorothiazide

Tablet

This fixed‑dose combination of Ramipril (ACE inhibitor) and Hydrochlorothiazide (thiazide diuretic) is used for effective management of hypertension, especially in patients requiring dual therapy.

Speciality	Cardiology \| Nephrology \| General Medicine
Tags	ACE Inhibitor \| Thiazide Diuretic \| Hypertension
Strength	Ramipril 5 mg Hydrochlorothiazide 12.5 mg
Packing Size	10 Tablets

Check all Tablet Range

Click to know More

Mechanism

Ramipril inhibits angiotensin‑converting enzyme (ACE), reducing angiotensin II levels and lowering blood pressure. Hydrochlorothiazide increases urinary excretion of sodium and water, reducing plasma volume. Together, they provide additive antihypertensive effects.

Pharmacokinetics

Ramipril Absorption: Rapidly absorbed; converted to active metabolite ramiprilat; peak plasma concentration in 2–4 hours.
Ramipril Distribution: Plasma protein binding ~73%; widely distributed.
Ramipril Excretion: Eliminated via urine and feces; half‑life of ramiprilat ~13–17 hours.
Hydrochlorothiazide Absorption: Well absorbed orally; peak plasma concentration in 1.5–4 hours.
Hydrochlorothiazide Bioavailability: ~60–80%.
Hydrochlorothiazide Excretion: Primarily excreted unchanged in urine; half‑life ~6–15 hours.

Side Effects

Dizziness
Fatigue
Hypotension
Hypokalemia (from Hydrochlorothiazide)
Hyperkalemia (from Ramipril)
Cough (ACE inhibitor related)

Contraindication

Hypersensitivity to Ramipril, Hydrochlorothiazide, or excipients
Pregnancy (teratogenic risk with ACE inhibitors)
Anuria or severe renal impairment
History of angioedema with ACE inhibitors

Interaction

Potassium‑sparing diuretics or supplements (risk of hyperkalemia)
NSAIDs (may reduce antihypertensive effect)
Other antihypertensives (additive effect)
Digitalis glycosides (risk of arrhythmias with electrolyte imbalance)

Warning and Precautions

Monitor renal function and electrolytes regularly
Use under medical supervision only
Caution in patients with diabetes or gout

Dosage

As directed by the Physician.

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.