Rabeprazole Tablets

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Therapeutic Indication

Gastroesophageal reflux disease (GERD)
Dyspepsia and acid-related disorders
Nausea and vomiting associated with reflux
Peptic ulcer disease
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Rabeprazole

Tablet

Rabeprazole is a proton pump inhibitor (PPI) used to reduce gastric acid secretion. It is prescribed for gastroesophageal reflux disease (GERD), peptic ulcer disease, dyspepsia, and Zollinger-Ellison syndrome.

Speciality Gastroenterology | Acid Suppression | Ulcer Management
Tags GERD | Acid Reflux | Peptic Ulcer | Proton Pump Inhibitor | Gastric Acid Suppression
Strength
  • 20 mg
  • 40 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Rabeprazole irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) in gastric parietal cells, leading to profound and sustained reduction of gastric acid secretion.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally; peak plasma levels in 3–4 hrs.
  • Distribution: ~96% plasma protein bound.
  • Metabolism: Extensively metabolized in liver via CYP2C19 & CYP3A4.
  • Excretion: Excreted via urine (~90%) and feces (~10%).
  • Half-life: ~1–2 hrs.

Side Effects

  • Hypersensitivity to Rabeprazole or other PPIs
  • Severe hepatic impairment (use cautiously)

Contraindication

  • Hypersensitivity to Rabeprazole or Domperidone
  • Severe hepatic impairment
  • Cardiac arrhythmias (Domperidone)

Interaction

  • May reduce absorption of drugs requiring acidic pH (e.g., ketoconazole, itraconazole)
  • May interact with warfarin (monitor INR)

Warning and Precautions

  • Do not exceed recommended daily dose
  • Monitor liver function during prolonged use
  • Long-term use may increase risk of osteoporosis-related fractures

Dosage

As directed by the Physician.

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