Rabeprazole + Domperidone Tablets

Therapeutic Indication

Gastroesophageal reflux disease (GERD)

Dyspepsia and acid-related disorders

Nausea and vomiting associated with reflux

Peptic ulcer disease

+91 85919 78885

Rabeprazole + Domperidone

Tablet

This combination provides dual action: Rabeprazole reduces gastric acid secretion, while Domperidone enhances gastric motility and prevents nausea. It is prescribed for GERD, acid reflux, dyspepsia, and nausea associated with delayed gastric emptying.

Speciality	Gastroenterology \| Acid Suppression \| Prokinetic Therapy
Tags	GERD \| Acid Reflux \| Dyspepsia \| Nausea Relief \| Proton Pump Inhibitor \| Prokinetic
Strength	Rabeprazole 20 mg/40 mg Domperidone 10 mg
Packing Size	10 Tablets

Check all Tablet Range

Click to know More

Mechanism

Rabeprazole: Proton pump inhibitor → irreversibly blocks H+/K+ ATPase in gastric parietal cells → reduces gastric acid secretion.
Domperidone: Dopamine D2 receptor antagonist → enhances gastric emptying and motility → reduces nausea and vomiting.

Pharmacokinetics

Absorption: Rabeprazole rapidly absorbed, peak plasma levels in 3–4 hrs; Domperidone absorbed orally with peak in ~30 min.
Distribution: Rabeprazole ~96% protein bound; Domperidone ~91–93% protein bound.
Metabolism: Rabeprazole metabolized hepatically via CYP2C19 & CYP3A4; Domperidone via CYP3A4.
Excretion: Rabeprazole excreted via urine and feces; Domperidone primarily via feces.
Half-life: Rabeprazole ~1–2 hrs; Domperidone ~7 hrs.

Side Effects

Headache
Diarrhea or constipation
Abdominal pain
Dry mouth
Rare: QT prolongation (Domperidone)

Contraindication

Hypersensitivity to Rabeprazole or Domperidone
Severe hepatic impairment
Cardiac arrhythmias (Domperidone)

Interaction

Rabeprazole may reduce absorption of drugs requiring acidic pH (e.g., ketoconazole)
Domperidone may interact with QT-prolonging drugs
Concurrent use with strong CYP3A4 inhibitors increases Domperidone levels

Warning and Precautions

Do not exceed recommended daily dose
Monitor liver function during prolonged use
Use cautiously in patients with cardiovascular disorders

Dosage

As directed by the Physician.

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.