Quinine Tablets

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Therapeutic Indication

Treatment of malaria (Plasmodium falciparum)
Relief of nocturnal leg cramps
Adjunct therapy in resistant malaria cases
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Quinine

Tablet

Quinine is an antimalarial drug derived from the bark of the cinchona tree. It is primarily used for the treatment of malaria caused by Plasmodium falciparum and is sometimes prescribed for nocturnal leg cramps. Quinine interferes with the parasite’s ability to digest hemoglobin, leading to its death.

Speciality Infectious Diseases | Internal Medicine
Tags Malaria | Antimalarial | Leg Cramps | Tropical Medicine
Strength
  • 200 mg
  • 300 mg
Packing Size
  • 21 Tablets

Check all Women Range

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Mechanism

Quinine interferes with the parasite’s ability to digest hemoglobin within red blood cells. It accumulates in the parasite’s food vacuole, disrupting heme detoxification and leading to toxic buildup that kills the parasite.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration.
  • Distribution: Widely distributed; crosses placenta and enters breast milk.
  • Metabolism: Extensively metabolized in the liver via CYP3A4.
  • Elimination: Excreted via urine.
  • Half-life: Approximately 11 hours.

Side Effects

  • Cinchonism (tinnitus, headache, nausea, visual disturbances)
  • Hypoglycemia
  • Hemolysis in G6PD deficiency
  • Arrhythmias
  • Allergic reactions

Contraindication

  • Hypersensitivity to quinine or related compounds
  • Optic neuritis
  • Pregnancy (use with caution)
  • G6PD deficiency

Interaction

  • Warfarin (enhanced anticoagulant effect)
  • Digoxin (increased plasma levels)
  • CYP3A4 inhibitors/inducers

Warning and Precautions

  • Monitor for signs of cinchonism
  • Use cautiously in cardiac patients
  • Regular monitoring of blood glucose
  • Not recommended for long-term use

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.