Quetiapine Tablets

Therapeutic Indication

Schizophrenia

Bipolar disorder (mania & depression)

Major depressive disorder (adjunct therapy)

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Quetiapine

Tablet

Quetiapine is an atypical antipsychotic that modulates dopamine and serotonin receptors, helping to stabilize mood and reduce psychotic symptoms. It is widely prescribed for schizophrenia, bipolar disorder, and as adjunct therapy in major depressive disorder.

Speciality	Psychiatry \| Neurology \| Internal Medicine
Tags	Antipsychotic \| Schizophrenia \| Bipolar Disorder \| Depression
Strength	50 mg 100 mg 2000 mg 300 mg
Packing Size	10 Tablets

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Mechanism

Quetiapine antagonizes dopamine D2 and serotonin 5-HT2 receptors, reducing psychotic symptoms and stabilizing mood. It also has affinity for histamine and adrenergic receptors, contributing to sedative effects.

Pharmacokinetics

Absorption: Well absorbed orally.
Metabolism: Extensively metabolized in liver via CYP3A4.
Excretion: Primarily via urine and feces.
Half-life: ~6 hours.

Side Effects

Drowsiness
Weight gain
Dry mouth
Dizziness
Constipation
Rare: Tardive dyskinesia, Neuroleptic Malignant Syndrome

Contraindication

Hypersensitivity to quetiapine
Severe hepatic impairment

Interaction

CYP3A4 inhibitors (ketoconazole, erythromycin)
Other CNS depressants (additive sedation)
Antihypertensives (enhanced hypotension)

Warning and Precautions

Monitor for metabolic changes (weight, glucose, lipids)
Use cautiously in elderly patients
Discontinue if severe EPS or tardive dyskinesia occurs
Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.