Pyridostigmine Tablets

Therapeutic Indication

Management of Myasthenia Gravis

Reversal of muscle relaxants after surgery

Paralytic ileus and post-operative urinary retention

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Pyridostigmine

Tablet

Pyridostigmine is an anticholinesterase medication that increases acetylcholine levels at neuromuscular junctions. It is primarily used to improve muscle strength in patients with myasthenia gravis and has additional applications in post-surgical care.

Speciality	Neurology \| Internal Medicine \| Anesthesiology
Tags	Myasthenia Gravis \| Anticholinesterase \| Muscle Strength \| Post-surgical Recovery
Strength	60 mg
Packing Size	10 Tablets

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Mechanism

Pyridostigmine inhibits acetylcholinesterase, preventing breakdown of acetylcholine. This enhances neuromuscular transmission and improves muscle contraction.

Pharmacokinetics

Absorption: Oral bioavailability ~10–20%; peak plasma concentration in 1–2 hours.
Protein Binding: Minimal.
Metabolism: Partially metabolized in the liver.
Excretion: Primarily via kidneys.
Half-life: ~1–2 hours (longer in renal impairment).

Side Effects

Nausea, diarrhea, abdominal cramps
Excessive salivation and sweating
Muscle twitching
Blurred vision
Severe weakness or breathing difficulty (overdose)

Contraindication

Hypersensitivity to Pyridostigmine
Mechanical obstruction of bladder or intestines
Asthma or severe respiratory disease (caution)

Interaction

Other cholinesterase inhibitors (additive effect)
Anticholinergic drugs (reduce effectiveness)
Neuromuscular blocking agents (interaction during anesthesia)

Warning and Precautions

Use under strict medical supervision
Monitor muscle strength and breathing regularly
Adjust dose in renal impairment
Do not stop suddenly without medical advice

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Please consult a healthcare professional before using any medicinal product.