Proguanil Tablets

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Therapeutic Indication

Malaria treatment (Plasmodium falciparum, vivax)
Malaria prophylaxis (travelers to endemic areas)
Combination therapy with Atovaquone (resistant strains)
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Proguanil

Tablet

An antimalarial drug that inhibits folic acid synthesis in parasites, preventing DNA replication and survival.

Speciality Infectious Diseases | Travel Medicine
Tags Malaria | Antimalarial | Prophylaxis | Travel Health
Strength
  • 100 mg
Packing Size
  • 10 Tablets

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Mechanism

Proguanil inhibits dihydrofolate reductase, blocking folic acid synthesis in parasites and preventing DNA replication.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally.
  • Metabolism: Converted to active metabolite cycloguanil in liver.
  • Excretion: Primarily via urine.
  • Half-life: ~12–20 hours.

Side Effects

  • Nausea
  • Headache
  • Abdominal pain
  • Diarrhea
  • Dizziness
  • Rare: Hair loss, liver dysfunction

Contraindication

  • Hypersensitivity to Proguanil
  • Severe renal impairment
  • Liver disease (use with caution)

Interaction

  • Warfarin (enhanced anticoagulant effect)
  • Phenytoin, Carbamazepine (reduced efficacy)
  • Antacids (reduce absorption)

Warning and Precautions

  • Complete full course even if symptoms improve
  • Use mosquito precautions alongside medication
  • Not recommended in pregnancy unless benefits outweigh risks

Dosage

As directed by the Physician.