Prochlorperazine Tablets

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Therapeutic Indication

Treatment of nausea and vomiting
Vertigo and dizziness
Adjunct in schizophrenia and psychotic disorders
Short-term management of severe anxiety
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Prochlorperazine

Tablet

Prochlorperazine is a phenothiazine derivative with antiemetic and antipsychotic properties. It is commonly prescribed for nausea, vomiting, vertigo, and psychiatric conditions such as schizophrenia. It works by blocking dopamine receptors in the brain.

Speciality Psychiatry | Gastroenterology | Neurology
Tags Antiemetic | Antipsychotic | Vertigo | Anxiety
Strength
  • 5 mg
  • 10 mg
Packing Size
  • 10 Tablets

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Mechanism

Prochlorperazine blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) of the brain, preventing nausea and vomiting. Its antipsychotic effects are due to dopamine antagonism in the mesolimbic pathway.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Distribution: Widely distributed; crosses blood-brain barrier.
  • Metabolism: Extensively metabolized in the liver.
  • Elimination: Excreted via urine and feces.
  • Half-life: Approximately 6–8 hours.

Side Effects

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Extrapyramidal symptoms (tremors, rigidity)
  • Hypotension

Contraindication

  • Hypersensitivity to phenothiazines
  • Severe CNS depression
  • Comatose states
  • Children under 2 years

Interaction

  • CNS depressants (additive sedation)
  • Antihypertensives (enhanced hypotension)
  • Levodopa (antagonistic effect)

Warning and Precautions

  • Monitor for extrapyramidal side effects
  • Use cautiously in patients with liver disease
  • Avoid alcohol and sedatives
  • Not recommended for long-term use without supervision

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.