Prednisolone Tablets

Mechanism

Prednisolone binds to glucocorticoid receptors, modulating gene expression and suppressing inflammatory mediators such as cytokines and prostaglandins. It reduces immune system activity, alleviating inflammation and allergic responses.

Pharmacokinetics

• Absorption: Rapid oral absorption.
• Distribution: Widely distributed; plasma protein binding ~70–90%.
• Metabolism: Hepatic metabolism.
• Elimination: Excreted in urine.
• Half-life: ~2–4 hours (biological effects longer).

Side Effects

• Weight gain
• Fluid retention
• Hypertension
• Hyperglycemia
• Osteoporosis (long-term use)
• Increased risk of infections

Contraindication

• Hypersensitivity to Prednisolone
• Systemic fungal infections
• Live vaccines during therapy

Interaction

• NSAIDs: Increased risk of GI bleeding.
• Antidiabetic drugs: Reduced efficacy due to hyperglycemia.
• Antihypertensives: May reduce effectiveness.
• Live vaccines: Contraindicated during therapy.

Warning and Precautions

• Monitor blood pressure, glucose, and bone density during long-term therapy.
• Gradual tapering required to avoid adrenal insufficiency.
• Use cautiously in patients with diabetes, hypertension, or osteoporosis.
• Advise patients to avoid exposure to infections.

Dosage

As directed by the Physician.