Pirfenidone Tablets

Therapeutic Indication

Idiopathic Pulmonary Fibrosis (IPF)

Slows progression of lung fibrosis

Helps preserve lung function

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Pirfenidone

Tablet

Pirfenidone is an antifibrotic and anti-inflammatory agent that reduces fibroblast proliferation and collagen synthesis. It is indicated for the treatment of idiopathic pulmonary fibrosis (IPF).

Speciality	Pulmonology \| Internal Medicine
Tags	Antifibrotic \| IPF Therapy
Strength	200 mg
Packing Size	10 Tablets

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Mechanism

Pirfenidone reduces fibroblast proliferation, inhibits transforming growth factor-beta (TGF-β) activity, and decreases collagen synthesis, thereby slowing fibrosis progression in the lungs.

Pharmacokinetics

Absorption: Rapid oral absorption
Metabolism: Hepatic via CYP1A2
Elimination: Renal excretion
Half-life: 2–2.5 hours

Side Effects

Nausea
Fatigue
Skin rash
Photosensitivity reactions

Contraindication

Severe hepatic impairment
Severe renal impairment
Hypersensitivity to Pirfenidone

Interaction

CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
Smoking may reduce drug levels

Warning and Precautions

Monitor liver function regularly
Avoid excessive sun exposure
Use with caution in renal impairment

Dosage

As directed by the Physician.