Pioglitazone + Metformin ER Tablets

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Therapeutic Indication

Type 2 Diabetes Mellitus
Insulin resistance
Adjunct to diet and exercise
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Pioglitazone

Tablet

This fixed-dose combination provides dual action: Pioglitazone improves insulin sensitivity, while Metformin ER reduces hepatic glucose production and enhances peripheral glucose uptake. It is prescribed for type 2 diabetes mellitus when monotherapy is insufficient.

Speciality Endocrinology | Diabetes Management | Insulin Sensitization
Tags Type 2 Diabetes | Oral Antidiabetic | Insulin Sensitizer | Biguanide | Combination Therapy
Strength
  • Pioglitazone 15 mg / 30 mg
  • Metformin ER 500 mg / 750 mg / 1000 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Pioglitazone: Thiazolidinedione → activates PPAR-γ receptors → increases insulin sensitivity in adipose tissue, muscle, and liver.
Metformin ER: Biguanide → decreases hepatic gluconeogenesis, increases peripheral glucose uptake, and reduces intestinal glucose absorption.

Pharmacokinetics

  • Absorption: Pioglitazone well absorbed orally; Metformin ER absorbed slowly with extended release profile.
  • Distribution: Pioglitazone ~99% protein bound; Metformin distributes widely, not protein bound.
  • Metabolism: Pioglitazone metabolized hepatically via CYP2C8; Metformin not metabolized significantly.
  • Excretion: Pioglitazone via bile and feces; Metformin excreted unchanged in urine.
  • Half-life: Pioglitazone ~3–7 hrs; Metformin ER ~6–8 hrs.

Side Effects

    li>Weight gain (Pioglitazone)
  • Edema and risk of heart failure (Pioglitazone)
  • Gastrointestinal upset (Metformin ER)
  • Rare: Lactic acidosis (Metformin)

Contraindication

  • Severe renal impairment (Metformin)
  • Congestive heart failure (Pioglitazone)
  • Hepatic impairment
  • Hypersensitivity to any component

Interaction

  • Alcohol increases risk of lactic acidosis (Metformin)
  • Pioglitazone may interact with CYP2C8 inhibitors (e.g., gemfibrozil)
  • Other antidiabetics may increase risk of hypoglycemia

Warning and Precautions

  • Monitor liver function regularly
  • Monitor renal and hepatic function regularly
  • Use cautiously in patients with cardiac disease
  • Advise patients to avoid excessive alcohol intake

Dosage

As directed by the Physician.