Paroxetine Tablets

Therapeutic Indication

Major depressive disorder

Generalized anxiety disorder

Panic disorder

Obsessive-compulsive disorder (OCD)

Social anxiety disorder

Post-traumatic stress disorder (PTSD)

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Paroxetine

Tablet

Paroxetine is a prescription antidepressant medication belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It works by restoring the balance of serotonin, a natural chemical in the brain, to help regulate mood, sleep, and anxiety.

Speciality	Psychiatry
Tags	SSRI \| Antidepressant \| Anxiolytic
Strength	10 mg 20 mg 30 mg 40 mg
Packing Size	10 Tablets

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Mechanism

Paroxetine selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, increasing serotonin availability in the synaptic cleft. Enhanced serotonergic neurotransmission improves mood, reduces anxiety, and alleviates obsessive-compulsive symptoms.

Pharmacokinetics

Absorption: Well absorbed orally; peak plasma concentration in 5–6 hours.
Distribution: Highly protein bound (~95%).
Metabolism: Extensively metabolized in the liver via CYP2D6.
Elimination: Excreted mainly in urine as metabolites.
Half-life: ~21 hours, supporting once-daily dosing.

Side Effects

Nausea
Drowsiness
Sexual dysfunction
Weight gain
Dry mouth
Insomnia

Contraindication

Hypersensitivity to paroxetine
Concurrent use with MAO inhibitors
Use with pimozide or thioridazine

Interaction

CYP2D6 inhibitors (e.g., fluoxetine): Increase plasma levels
MAO inhibitors: Risk of serotonin syndrome
NSAIDs/anticoagulants: Increased bleeding risk

Warning and Precautions

Monitor for suicidal ideation, especially in young adults
Gradual tapering recommended to avoid withdrawal symptoms
Use cautiously in hepatic or renal impairment
Monitor weight and metabolic parameters

Dosage

As directed by the Physician.