Paracetamol + Caffeine + Chlorpheniramine Tablets

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Therapeutic Indication

Headache and migraine relief
Cold and flu symptoms
Allergic rhinitis
Fever management
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Paracetamol + Caffeine + Chlorpheniramine

Tablet

This combination provides Paracetamol (analgesic and antipyretic), Caffeine (CNS stimulant that enhances analgesic effect), and Chlorpheniramine (antihistamine for allergy and cold symptoms). It is commonly used for headache, cold, flu, and allergic rhinitis relief.

Speciality Psychiatry | Neurology
Tags Schizophrenia | Bipolar Disorder | Depression
Strength
  • 5 mg
  • 10 mg
  • 15 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Paracetamol: Inhibits prostaglandin synthesis in the CNS, reducing pain and fever.
Caffeine: Stimulates CNS, increases alertness, and potentiates analgesic action.
Chlorpheniramine: Blocks H1 histamine receptors, reducing allergy symptoms like sneezing and runny nose.

Pharmacokinetics

  • Absorption: Rapidly absorbed from GI tract.
  • Distribution: Paracetamol widely distributed; Caffeine crosses BBB; Chlorpheniramine distributes to tissues.
  • Metabolism: Paracetamol metabolized in liver; Caffeine metabolized by CYP1A2; Chlorpheniramine metabolized hepatically.
  • Elimination: Paracetamol via urine; Caffeine via urine; Chlorpheniramine via renal excretion.
  • Half-life: Paracetamol ~2–3 hrs; Caffeine ~5 hrs; Chlorpheniramine ~20 hrs.

Side Effects

  • Drowsiness (Chlorpheniramine)
  • Insomnia or jitteriness (Caffeine)
  • Nausea, vomiting
  • Rare: Liver toxicity (Paracetamol overdose)
  • Dry mouth, blurred vision

Contraindication

  • Hypersensitivity to any component
  • Severe hepatic impairment
  • Cardiac arrhythmias (avoid caffeine)
  • Glaucoma (avoid chlorpheniramine)
  • Pregnancy and lactation (use with caution)

Interaction

  • Alcohol (increases hepatotoxicity risk with Paracetamol)
  • MAO inhibitors (enhanced anticholinergic effect with Chlorpheniramine)
  • CNS stimulants (additive effect with Caffeine)
  • Warfarin (Paracetamol may increase INR with prolonged use)

Warning and Precautions

  • Do not exceed recommended Paracetamol dose (risk of liver damage)
  • Use cautiously in patients with hypertension or arrhythmias
  • May cause drowsiness — avoid driving or operating machinery
  • Monitor liver function in long-term use