Oxybutynin Tablets

Therapeutic Indication

Overactive bladder with symptoms of urinary urgency and frequency

Urinary incontinence

Neurogenic bladder (spinal cord injury, multiple sclerosis)

Nocturia and urgency associated with detrusor overactivity

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Oxybutynin

Tablet

Oxybutynin is an antimuscarinic agent used to treat overactive bladder and urinary incontinence. It works by relaxing bladder smooth muscle, reducing involuntary contractions, and improving bladder storage capacity.

Speciality	Urology \| Nephrology \| General Medicine
Tags	Overactive Bladder \| Urinary Incontinence \| Antimuscarinic
Strength	2.5 mg 5 mg
Packing Size	10 Tablets

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Mechanism

Oxybutynin competitively inhibits muscarinic receptors (M1, M2, M3) in bladder smooth muscle. This reduces involuntary detrusor contractions, increases bladder capacity, and decreases urinary urgency and frequency. It also has mild local anesthetic and antispasmodic effects.

Pharmacokinetics

Absorption: Rapidly absorbed orally
Distribution: Widely distributed; crosses blood-brain barrier
Metabolism: Extensively metabolized in the liver via CYP3A4
Half-life: ~2–3 hours
Excretion: Metabolites excreted in urine

Side Effects

Nausea
Dry mouth
Constipation
Drowsiness
Blurred vision
Cognitive impairment (elderly)

Contraindication

Hypersensitivity to Oxybutynin
Urinary retention
Gastric retention
Narrow-angle glaucoma

Interaction

Other anticholinergics: additive side effects
CYP3A4 inhibitors (e.g., ketoconazole): ↑ Oxybutynin levels
Alcohol/CNS depressants: additive sedation

Warning and Precautions

Use caution in elderly patients (risk of confusion)
Monitor for urinary retention
May impair ability to drive or operate machinery
Adjust dose in hepatic impairment

Dosage

As directed by the Physician.