Oxaceprol SR Tablets

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Therapeutic Indication

Chronic immune thrombocytopenia (ITP)
Severe aplastic anemia (refractory cases)
Thrombocytopenia associated with chronic hepatitis C
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Oxaceprol SR

Tablet

Oxaceprol is a derivative of proline with anti-inflammatory properties. It reduces leukocyte adhesion and migration into inflamed tissues, thereby alleviating pain and swelling in osteoarthritis and degenerative joint conditions. The sustained release formulation ensures prolonged therapeutic effect and improved patient compliance.

Speciality Orthopedics | Rheumatology | Pain Management
Tags Osteoarthritis | Anti-inflammatory | Joint Pain Relief | Sustained Release
Strength
  • 600 mg
Packing Size
  • 10 Tablets

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Mechanism

Oxaceprol inhibits leukocyte adhesion to endothelial cells and reduces migration into inflamed tissues. This leads to decreased release of inflammatory mediators, reduced tissue damage, and relief of pain and swelling in osteoarthritis.

Pharmacokinetics

  • Absorption: Well absorbed orally; sustained release ensures prolonged plasma levels.
  • Distribution: Widely distributed in connective tissues.
  • Metabolism: Minimal hepatic metabolism; largely excreted unchanged.
  • Elimination: Excreted via urine.
  • Half-life: ~5–7 hours (extended with SR formulation).

Side Effects

  • Mild gastrointestinal discomfort
  • Nausea
  • Dizziness
  • Rare: hypersensitivity reactions

Contraindication

  • Hypersensitivity to Oxaceprol or excipients
  • Severe renal impairment
  • Pregnancy and lactation — use cautiously

Interaction

  • No major drug interactions reported.
  • Safe with NSAIDs and analgesics (adjunctive use).

Warning and Precautions

  • Monitor liver function tests regularly.
  • Assess platelet counts frequently to avoid thrombosis.
  • Do not use for myelodysplastic syndromes (risk of progression to AML).
  • Take on an empty stomach, away from dairy or mineral supplements.