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Therapeutic Indication

Amebiasis (intestinal and hepatic)

Giardiasis

Trichomoniasis

Prophylaxis and treatment of anaerobic infections

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Ornidazole

Tablet

Ornidazole is a nitroimidazole derivative with antiprotozoal and antibacterial activity, used in the treatment of protozoal infections and anaerobic bacterial infections.

Speciality	Gastroenterology \| Infectious Diseases
Tags	Amebiasis \| Giardiasis \| Trichomoniasis \| Anaerobic Infections
Strength	500 mg
Packing Size	10 Tablets

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Mechanism

Ornidazole disrupts DNA synthesis in susceptible organisms by generating free radicals, leading to cell death in protozoa and anaerobic bacteria.

Pharmacokinetics

Absorption: Rapidly absorbed orally.
Metabolism: Metabolized in liver.
Excretion: Primarily via urine.
Half-life: ~12–14 hours.

Side Effects

Nausea
Headache
Dizziness
Metallic taste
Rare: Peripheral neuropathy

Contraindication

Hypersensitivity to nitroimidazoles
Pregnancy (especially first trimester)
Neurological disorders

Interaction

Alcohol (disulfiram-like reaction)
Warfarin (enhanced anticoagulant effect)

Warning and Precautions

Avoid alcohol during and 72 hours after therapy
Use with caution in patients with CNS disorders
Monitor liver function in prolonged use

Dosage

As directed by the Physician.

Ornidazole Tablets