Omega Fatty Acids + Selenium + Lycopene Tablets

Mechanism

Omega-3 Fatty Acids (EPA & DHA):

• EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid) are incorporated into phospholipid membranes, altering membrane fluidity and receptor function.
• They reduce synthesis of pro-inflammatory eicosanoids (like prostaglandin E2 and leukotriene B4) and promote anti-inflammatory mediators (resolvins, protectins).
• EPA lowers triglyceride levels by reducing hepatic VLDL synthesis and enhancing β-oxidation of fatty acids.
• DHA supports neuronal membrane integrity, synaptic plasticity, and neurotransmitter release, improving cognitive and visual functions.
• Both improve endothelial function, reduce platelet aggregation, and enhance blood flow, lowering cardiovascular risk.

Lycopene:

• A carotenoid with strong singlet oxygen quenching ability, neutralizing free radicals and reducing oxidative stress.
• Modulates gene expression related to cell cycle regulation, apoptosis, and antioxidant defense.
• Inhibits LDL oxidation, reducing atherosclerotic plaque formation.
• Protects DNA from oxidative damage, lowering risk of mutagenesis and carcinogenesis.
• Supports prostate health by downregulating IGF-1 signaling and reducing inflammatory cytokines.

Selenium:

• Essential trace element incorporated into selenoproteins such as glutathione peroxidase and thioredoxin reductase.
• These enzymes catalyze reduction of hydrogen peroxide and lipid hydroperoxides, protecting cells from oxidative damage.
• Selenium regenerates Vitamin E and Vitamin C, enhancing the antioxidant network.
• Supports thyroid hormone metabolism via iodothyronine deiodinases, regulating energy balance and growth.
• Modulates immune response by enhancing T-cell proliferation and antibody production.

Pharmacokinetics

• Absorption: Omega-3 fatty acids are absorbed in the small intestine; Lycopene absorption enhanced with dietary fat; Selenium absorbed efficiently.
• Distribution: EPA & DHA incorporated into cell membranes, especially in brain, retina, and cardiovascular tissues.
• Metabolism: Omega-3s metabolized in the liver via β-oxidation; Lycopene metabolized into various oxidative derivatives; Selenium incorporated into selenoproteins.
• Elimination: Omega-3s excreted via urine and bile; Lycopene via feces; Selenium primarily via urine.
• Half-life: EPA/DHA ~2–3 days; Lycopene ~2–3 days; Selenium ~1 day depending on status.

Side Effects

• Nausea, diarrhea, abdominal pain
• Taste perversion, rash, elevated ALT, increased LDL-C (long-term use)

Contraindication

• Pregnancy & lactation
• Children
• Active GI ulceration or chronic inflammation
• Pre-existing renal disease
• Hypersensitivity to NSAIDs or Tranexamic Acid

Interaction

• Use cautiously with Warfarin and other anticoagulants
• Potential interactions with Statins (HMG-CoA reductase inhibitors)

Warning and Precautions

• Monitor renal and hepatic function during prolonged therapy
• Use with caution in patients with thromboembolic risk
• Discontinue if GI bleeding or ulceration occurs
• Not recommended in pediatric patients

Dosage

As directed by the Physician.