Olmesartan + Hydrochlorothiazide Tablets

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Therapeutic Indication

Hypertension (blood pressure management)
Adjunct therapy in patients uncontrolled on monotherapy
Cardiovascular risk reduction
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Olmesartan + Hydrochlorothiazide

Tablet

This fixed‑dose combination of Olmesartan (angiotensin II receptor blocker) and Hydrochlorothiazide (thiazide diuretic) is used for effective management of hypertension, especially in patients requiring dual therapy.

Speciality Cardiology | Nephrology | General Medicine
Tags ARB | Thiazide Diuretic | Hypertension
Strength
  • Olmesartan 20 mg/40 mg
  • Hydrochlorothiazide 12.5 mg
Packing Size
  • 10 Tablets

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Mechanism

Olmesartan selectively blocks angiotensin II receptors, preventing vasoconstriction and lowering blood pressure. Hydrochlorothiazide increases urinary excretion of sodium and water, reducing plasma volume. Together, they provide additive antihypertensive effects.

Pharmacokinetics

  • Olmesartan Absorption: Oral bioavailability ~26%; peak plasma concentration in 1–2 hours.
  • Olmesartan Distribution: Plasma protein binding ~99%; widely distributed.
  • Olmesartan Excretion: Eliminated via feces (~60%) and urine (~40%); half‑life ~13 hours.
  • Hydrochlorothiazide Absorption: Well absorbed orally; peak plasma concentration in 1.5–4 hours.
  • Hydrochlorothiazide Bioavailability: ~60–80%.
  • Hydrochlorothiazide Excretion: Primarily excreted unchanged in urine; half‑life ~6–15 hours.

Side Effects

  • Dizziness
  • Fatigue
  • Hypotension
  • Hypokalemia (from Hydrochlorothiazide)
  • Hyperkalemia (rare, from Olmesartan)
  • Headache

Contraindication

  • Hypersensitivity to Olmesartan, Hydrochlorothiazide, or excipients
  • Pregnancy (especially 2nd and 3rd trimester)
  • Anuria or severe renal impairment
  • Severe hepatic impairment

Interaction

  • Potassium‑sparing diuretics or supplements (risk of hyperkalemia)
  • NSAIDs (may reduce antihypertensive effect)
  • Other antihypertensives (additive effect)
  • Digitalis glycosides (risk of arrhythmias with electrolyte imbalance)

Warning and Precautions

  • Monitor renal function and electrolytes regularly
  • Use under medical supervision only
  • Caution in patients with diabetes or gout

Dosage

As directed by the Physician.