Ofloxacin + Tinidazole Tablets

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Therapeutic Indication

Gastrointestinal infections (amoebiasis, giardiasis)
Urinary tract infections
Gynecological infections
Mixed bacterial and protozoal infections
Post-surgical prophylaxis
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Ofloxacin + Tinidazole

Tablet

This fixed-dose combination provides dual coverage against bacterial and protozoal pathogens. Ofloxacin, a fluoroquinolone antibiotic, inhibits bacterial DNA gyrase and topoisomerase IV, while Tinidazole, a nitroimidazole derivative, disrupts DNA synthesis in anaerobic bacteria and protozoa.

Speciality Gastroenterology | Urology | Gynecology | General Medicine
Tags Antibiotic | Antiprotozoal | GI Infections | UTI
Strength
  • Ofloxacin 200 mg
  • Tinidazole 500 mg
Packing Size
  • 10 Tablets

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Mechanism

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription. Tinidazole enters protozoal and anaerobic bacterial cells, causing DNA strand breakage and cell death.

Pharmacokinetics

  • Ofloxacin: Rapid oral absorption (~90% bioavailability); widely distributed; metabolized in liver; excreted via urine; half-life ~5–7 hours.
  • Tinidazole: Rapid oral absorption (~100% bioavailability); widely distributed including placenta and breast milk; metabolized in liver; excreted via urine and feces; half-life ~12–14 hours.

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Metallic taste (Tinidazole)
  • Dizziness

Contraindication

  • Hypersensitivity to fluoroquinolones or nitroimidazoles
  • Pregnancy and lactation (use with caution)
  • Severe hepatic impairment

Interaction

  • Antacids (reduce Ofloxacin absorption)
  • Alcohol (disulfiram-like reaction with Tinidazole)
  • Warfarin (enhanced anticoagulant effect)
  • NSAIDs (increase seizure risk with fluoroquinolones)

Warning and Precautions

  • Use under medical supervision only
  • Caution in patients with seizure disorders
  • Monitor liver function during prolonged therapy

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.