Nortriptyline Tablets

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Therapeutic Indication

Depression
Neuropathic pain
Diabetic neuropathy
Post-herpetic neuralgia
Chronic pain syndromes
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Nortriptyline

Tablet

Nortriptyline is a tricyclic antidepressant (TCA) used for the treatment of depression and neuropathic pain. It works by restoring the balance of neurotransmitters in the brain, improving mood and reducing pain perception. It is widely used in chronic pain management and nerve-related disorders due to its dual benefit.

Speciality Tricyclic Antidepressant (TCA)
Tags Mood Stabilizer | Neuropathic Relief | Chronic Pain Care
Strength
  • 25 mg
Packing Size
  • 10 Tablets

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Mechanism

Nortriptyline inhibits the reuptake of norepinephrine and serotonin in the central nervous system, increasing their levels and enhancing neurotransmission. In neuropathic pain, it modulates pain pathways by enhancing descending inhibitory pathways in the spinal cord, reducing pain signal transmission. It also exhibits mild anticholinergic and sedative effects, contributing to improved sleep and pain relief in chronic conditions.

Pharmacokinetics

  • Absorption: Well absorbed orally
  • Distribution: Widely distributed in tissues
  • Metabolism: Hepatic (CYP2D6)
  • Elimination: Mainly via urine

Side Effects

  • Drowsiness
  • Dry mouth
  • Constipation
  • Dizziness

Contraindication

  • Recent myocardial infarction
  • Hypersensitivity to TCAs
  • Use with MAO inhibitors

Interaction

  • MAO inhibitors
  • SSRIs (increase toxicity risk)
  • Alcohol and CNS depressants

Warning and Precautions

  • Monitor for suicidal thoughts in early treatment
  • Use cautiously in cardiac patients
  • Avoid abrupt discontinuation
  • Use under medical supervision