Norfloxacin + Tinidazole Tablets

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Therapeutic Indication

Gastrointestinal infections
Urinary tract infections
Gynecological infections
Mixed bacterial and protozoal infections
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Norfloxacin + Tinidazole

Tablet

Norfloxacin is a synthetic, broad-spectrum antibacterial agent. Norfloxacin is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.
Tinidazole is an anti-parasitic drug used against protozoan infections. Tinidazole is used to treat trichomoniasis (a sexually transmitted disease that can affect men and women), giardiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps), and amebiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps and can spread to other organs such as the liver). Tinidazole is in a class of medications called antiprotozoal agents. It works by killing the organisms that can cause infection.

Speciality Infectious Diseases | Gastroenterology | Gynecology
Tags Antibiotic | Antiprotozoal | Combination Therapy
Strength
  • Norfloxacin 400 mg
  • Tinidazole 600 mg
Packing Size
  • 10 Tablets

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Mechanism

Norfloxacin inhibits bacterial DNA gyrase, preventing DNA replication and transcription. Tinidazole disrupts DNA structure in protozoa and anaerobic bacteria, leading to cell death. Together, they provide broad‑spectrum coverage against mixed infections.

Pharmacokinetics

  • Norfloxacin Absorption: Moderately absorbed; peak plasma concentration in 1–2 hours.
  • Norfloxacin Bioavailability: ~30–40%.
  • Norfloxacin Half-life: ~3–4 hours; excreted mainly via urine.
  • Tinidazole Absorption: Rapidly absorbed; peak plasma concentration in 2 hours.
  • Tinidazole Bioavailability: ~100% oral bioavailability.
  • Tinidazole Distribution: Widely distributed; crosses placenta and enters breast milk.
  • Tinidazole Excretion: Eliminated via urine and feces; half‑life ~12–14 hours.

Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Metallic taste (Tinidazole)

Contraindication

  • Hypersensitivity to fluoroquinolones or nitroimidazoles
  • Pregnancy and lactation (Tinidazole)
  • Severe renal or hepatic impairment

Interaction

  • Antacids (reduce Norfloxacin absorption)
  • Warfarin (Tinidazole may enhance anticoagulant effect)
  • Alcohol (disulfiram‑like reaction with Tinidazole)

Warning and Precautions

  • Use under medical supervision only
  • Monitor renal and hepatic function
  • Avoid alcohol during Tinidazole therapy

Dosage

As directed by the Physician.