Nimesulide Tablets

Mechanism

Nimesulide selectively inhibits cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis responsible for pain, fever, and inflammation.

Pharmacokinetics

• Absorption: Rapidly absorbed orally.
• Metabolism: Extensively metabolized in liver.
• Excretion: Primarily via urine and feces.
• Half-life: ~2–5 hours.

Side Effects

• Nausea, vomiting
• Diarrhea
• Dizziness
• Skin rash
• Rare: hepatotoxicity

Contraindication

• Hypersensitivity to NSAIDs
• Severe hepatic impairment
• Pregnancy and lactation
• History of gastrointestinal bleeding

Interaction

• Other NSAIDs (increased GI risk)
• Anticoagulants (enhanced bleeding risk)
• Alcohol (increased hepatotoxicity)

Warning and Precautions

• Use only for short-term treatment
• Monitor liver function during therapy
• Not recommended in children under 12 years
• Discontinue if signs of liver damage appear

Dosage

As directed by the Physician.