Nimesulide + Serratiopeptidase Tablets

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Therapeutic Indication

Pain relief
Fever reduction
Inflammatory conditions
Musculoskeletal pain
Dysmenorrhea
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Nimesulide + Serratiopeptidase

Tablet

This combination provides dual action: Nimesulide offers analgesic and anti-inflammatory effects, while Serratiopeptidase reduces swelling and promotes faster tissue recovery. It is prescribed for musculoskeletal pain, post-surgical inflammation, and traumatic injuries.

Speciality Internal Medicine | Orthopedics | Gynecology
Tags Analgesic | NSAID | Anti-inflammatory | Enzyme Therapy | Combination Tablet
Strength
  • Nimesulide 100 mg
  • Serratiopeptidase 10 mg
Packing Size
  • 10 Tablets

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Mechanism

Nimesulide: Selective COX-2 inhibitor → reduces prostaglandin synthesis → pain & inflammation relief.
Serratiopeptidase: Proteolytic enzyme → breaks down inflammatory mediators → reduces swelling & promotes healing.

Pharmacokinetics

  • Absorption: Nimesulide is rapidly absorbed orally with peak plasma levels in 1.5–3 hrs; Serratiopeptidase is absorbed from the intestine and reaches systemic circulation bound to alpha-2 macroglobulin.
  • Distribution: Nimesulide is ~99% plasma protein bound; Serratiopeptidase distributes to inflamed tissues.
  • Metabolism: Nimesulide undergoes hepatic metabolism via CYP enzymes; Serratiopeptidase is metabolized as a protein enzyme.
  • Excretion: Nimesulide is primarily excreted via urine and bile; Serratiopeptidase is eliminated through renal pathways.
  • Half-life: Nimesulide ~2–5 hrs; Serratiopeptidase ~1 hr (enzyme activity dependent).

Side Effects

  • Gastrointestinal upset
  • Hepatotoxicity risk (Nimesulide)
  • Allergic reactions (rare)
  • Nausea or dizziness

Contraindication

  • Severe hepatic impairment
  • Hypersensitivity to NSAIDs or enzymes
  • Pregnancy & lactation (use cautiously)

Interaction

  • Alcohol increases hepatotoxicity risk with Nimesulide
  • May interact with anticoagulants (↑ bleeding risk)
  • Other NSAIDs increase GI side effect risk

Warning and Precautions

  • Do not exceed recommended daily dose
  • Monitor liver function during prolonged use
  • Use cautiously in patients with bleeding disorders

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.