Nimesulide + Paracetamol Tablets

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Therapeutic Indication

Pain relief
Fever reduction
Inflammatory conditions
Musculoskeletal pain
Dysmenorrhea
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Nimesulide + Paracetamol

Tablet

This combination provides synergistic analgesic and antipyretic effects, commonly prescribed for pain, fever, and inflammatory conditions.

Speciality Internal Medicine | Orthopedics | Gynecology
Tags NSAID | Analgesic | Antipyretic | Combination therapy
Strength
  • Nimesulide 100 mg
  • Paracetamol 325 mg
Packing Size
  • 10 Tablets

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Mechanism

Nimesulide inhibits COX-2, reducing prostaglandin synthesis, while Paracetamol acts centrally to reduce fever and pain.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally.
  • Metabolism: Nimesulide metabolized in liver; Paracetamol via hepatic conjugation.
  • Excretion: Primarily via urine.
  • Half-life: Nimesulide ~2–5 hours; Paracetamol ~2–3 hours.

Side Effects

  • Nausea, vomiting
  • Diarrhea
  • Dizziness
  • Skin rash
  • Rare: hepatotoxicity

Contraindication

  • Hypersensitivity to NSAIDs or Paracetamol
  • Severe hepatic impairment
  • Pregnancy and lactation
  • History of gastrointestinal bleeding

Interaction

  • Other hepatotoxic drugs (increased risk)
  • Alcohol (enhanced liver toxicity)
  • Anticoagulants (increased bleeding risk)

Warning and Precautions

  • Use only for short-term treatment
  • Monitor liver function during therapy
  • Not recommended in children under 12 years
  • Discontinue if signs of liver damage appear

Dosage

As directed by the Physician.