Nimesulide + Paracetamol + Cetirizine + Phenylpropanolamine + Caffeine Tablets

Therapeutic Indication

Pain relief and fever reduction

Allergic rhinitis and urticaria

Nasal congestion relief

>Alertness and reduced drowsiness

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Nimesulide + Cetirizine + Combination Tablets

Tablet

This combination formulation provides analgesic, antipyretic, antihistaminic, decongestant, and stimulant effects. It is prescribed for pain, fever, allergy symptoms, nasal congestion, and to reduce drowsiness associated with antihistamines.

Speciality	Pain Relief \| Antipyretic \| Anti-inflammatory \| Anti-allergy \| Decongestant \| Stimulant
Tags	Analgesic \| Antipyretic \| NSAID \| Antihistamine \| Decongestant \| Stimulant \| Combination Therapy
Strength	Nimesulide – 100 mg Paracetamol – 325 mg Cetirizine – 5 mg Phenylpropanolamine – 25 mg Caffeine – 30 mg
Packing Size	10 Tablets

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Mechanism

Nimesulide: Inhibits COX-2 enzyme, reducing prostaglandin synthesis and inflammation.
Paracetamol: Acts centrally to reduce fever and pain by inhibiting prostaglandin synthesis in the CNS.
Cetirizine: Antihistamine that blocks H1 receptors, reducing allergy symptoms.
Phenylpropanolamine: Sympathomimetic agent that reduces nasal congestion by vasoconstriction.
Caffeine: CNS stimulant that reduces drowsiness and enhances alertness.

Pharmacokinetics

Absorption: Rapidly absorbed orally; Paracetamol peaks within 30–60 min, Cetirizine within ~1 hr, Caffeine within 30–60 min.
Distribution: Nimesulide ~99% protein bound; Paracetamol widely distributed with low protein binding; Cetirizine minimal CNS penetration; Caffeine crosses blood-brain barrier.
Metabolism: Nimesulide metabolized hepatically via CYP enzymes; Paracetamol via glucuronidation & sulfation; Cetirizine limited hepatic metabolism; Phenylpropanolamine minimal metabolism; Caffeine via CYP1A2.
Excretion: Primarily renal excretion for Paracetamol, Cetirizine, Phenylpropanolamine, and Caffeine; Nimesulide via urine and bile.
Half-life: Nimesulide ~2–5 hrs; Paracetamol ~2–3 hrs; Cetirizine ~8–10 hrs; Phenylpropanolamine ~3–4 hrs; Caffeine ~3–6 hrs.

Side Effects

Gastrointestinal upset (Nimesulide/Paracetamol)
Hepatotoxicity risk with prolonged use (Nimesulide/Paracetamol)
Drowsiness or sedation (Cetirizine)
Palpitations, hypertension (Phenylpropanolamine)
Insomnia, nervousness (Caffeine)
Rare allergic reactions

Contraindication

Hepatic impairment (Nimesulide/Paracetamol)
Hypersensitivity to NSAIDs or antihistamines
Hypertension and cardiovascular disease (Phenylpropanolamine)
Pregnancy & lactation (use cautiously)

Interaction

Alcohol increases hepatotoxicity risk with Paracetamol/Nimesulide
Phenylpropanolamine may interact with MAO inhibitors
Caffeine may enhance stimulant effects of other drugs
Cetirizine may cause additive sedation with CNS depressants

Warning and Precautions

Do not exceed recommended daily dose
Monitor liver function during prolonged use
Use cautiously in patients with cardiovascular disorders
Do not combine with other CNS stimulants

Dosage

As directed by the Physician.