Nimesulide + Dicyclomine Tablets

Therapeutic Indication

Abdominal pain and cramps

Irritable Bowel Syndrome (IBS)

Dysmenorrhea (painful menstruation)

Intestinal and biliary colic

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Nimesulide + Dicyclomine

Tablet

Combination medicine used for abdominal pain and cramps. Dicyclomine acts as an antispasmodic, while Nimesulide reduces inflammation and pain.

Speciality	Gastroenterology \| Gynecology \| Internal Medicine
Tags	Antispasmodic \| NSAID \| Pain Relief
Strength	Nimesulide 1000 mg Dicyclomine 20 mg
Packing Size	10 Tablets

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Mechanism

Dicyclomine relaxes smooth muscles of the gut, reducing cramps. Nimesulide inhibits COX-2 enzymes, lowering prostaglandins and inflammation.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Wide tissue distribution.
Metabolism: Hepatic metabolism.
Elimination: Renal excretion.
Half-life: Nimesulide ~1.8–4.7 hrs; Dicyclomine ~1.8 hrs.

Side Effects

Nausea, vomiting
Dry mouth, dizziness
Blurred vision, weakness
Liver toxicity (rare but serious)

Contraindication

Severe liver or kidney disease
Glaucoma, enlarged prostate
Active stomach ulcer or GI bleeding
Hypersensitivity to either drug

Interaction

Other anticholinergics (atropine, scopolamine)
Tricyclic antidepressants (amitriptyline, imipramine)
Anticoagulants (warfarin, heparin)
Other NSAIDs (aspirin, ibuprofen)

Warning and Precautions

Take with food to reduce gastric irritation
Avoid alcohol (increases liver toxicity)
Not recommended for children under 12 years

Dosage

As directed by the Physician.

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