Nimesulide + Cetirizine + Phenylephrine Tablets

Therapeutic Indication

Pain relief and fever reduction

Allergic rhinitis and urticaria

Nasal congestion relief

>Alertness and reduced drowsiness

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Nimesulide + Cetirizine + Phenylephrine Tablets

Tablet

This combination provides analgesic, antipyretic, antihistaminic, and decongestant effects. It is prescribed for pain, fever, allergy symptoms, and nasal congestion associated with cold or flu.

Speciality	Pain Relief \| Antipyretic \| Anti-inflammatory \| Anti-allergy \| Decongestant
Tags	Analgesic \| Antipyretic \| NSAID \| Antihistamine \| Decongestant \| Combination Therapy
Strength	Nimesulide 100 mg Cetirizine 5 mg Phenylephrine 10 mg
Packing Size	10 Tablets

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Mechanism

Nimesulide: Selective COX-2 inhibitor → reduces prostaglandin synthesis → pain & inflammation relief.
Cetirizine: H1 receptor antagonist → reduces histamine-mediated allergy symptoms.
Phenylephrine: Sympathomimetic agent → vasoconstriction → nasal decongestion.

Pharmacokinetics

Absorption: Rapidly absorbed orally; Paracetamol peaks within 30–60 min, Cetirizine within ~1 hr, Phenylephrine within 1–2 hrs.
Distribution: Nimesulide ~99% protein bound; Cetirizine minimal CNS penetration; Phenylephrine widely distributed.
Metabolism: Nimesulide via hepatic CYP enzymes; Cetirizine limited hepatic metabolism; Phenylephrine undergoes hepatic metabolism.
Excretion: Primarily renal excretion for Cetirizine & Phenylephrine; Nimesulide via urine and bile.
Half-life: Nimesulide ~2–5 hrs; Cetirizine ~8–10 hrs; Phenylephrine ~2–3 hrs.

Side Effects

Gastrointestinal upset (Nimesulide)
Hepatotoxicity risk with prolonged use (Nimesulide)
Drowsiness or sedation (Cetirizine)
Palpitations, hypertension (Phenylephrine)
Rare allergic reactions

Contraindication

Severe hepatic impairment
Hypersensitivity to NSAIDs or antihistamines
Hypertension & cardiovascular disease (Phenylephrine)
Pregnancy & lactation (use cautiously)

Interaction

Alcohol increases hepatotoxicity risk with Nimesulide
Phenylephrine may interact with MAO inhibitors
Cetirizine may cause additive sedation with CNS depressants

Warning and Precautions

Do not exceed recommended daily dose
Monitor liver function during prolonged use
Use cautiously in patients with cardiovascular disorders
Consult physician before combining with other supplements or medications

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.