Nifedipine Prolonged Release Tablets | SR Calcium Channel Blocker for Hypertension

Therapeutic Indication

Hypertension (24-hour BP control)

Chronic stable angina

Vasospastic angina

Long-term cardiovascular management

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Nifedipine Prolonged Release

Tablet

Nifedipine Prolonged Release Tablets are designed for sustained and controlled release of the drug over 24 hours, ensuring stable blood pressure control and long-lasting anti-anginal effect. This formulation improves patient compliance by reducing dosing frequency and minimizing fluctuations in drug levels. It provides smooth vasodilation and consistent cardiovascular protection.

Speciality	Calcium Channel Blocker (Sustained Release)
Tags	24-Hour Control \| BP Management \| Anti-anginal
Strength	10 mg 20 mg 30 mg
Packing Size	10 Tablets

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Mechanism

Nifedipine inhibits L-type calcium channels in vascular smooth muscle, reducing calcium influx and causing arterial vasodilation. This leads to decreased peripheral vascular resistance and lower blood pressure. The prolonged release formulation ensures gradual drug release, maintaining steady plasma concentrations over 24 hours. This minimizes peak-trough fluctuations, reduces side effects like reflex tachycardia, and provides consistent therapeutic effect. It also improves coronary blood flow, reducing myocardial oxygen demand and preventing angina episodes.

Pharmacokinetics

Absorption: Slow and controlled release
Distribution: High plasma protein binding
Metabolism: Hepatic (CYP3A4)
Elimination: Primarily via urine

Side Effects

Headache
Flushing
Dizziness
Peripheral edema

Contraindication

Severe hypotension
Cardiogenic shock
Hypersensitivity to Nifedipine

Interaction

CYP3A4 inhibitors (ketoconazole, erythromycin)
Beta-blockers
Grapefruit juice

Warning and Precautions

Do not crush or chew SR tablets
Monitor blood pressure regularly
Use cautiously in heart failure
Use under medical supervision