Nicoumalone Tablets

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Therapeutic Indication

Prevention and treatment of deep vein thrombosis (DVT)
Prevention of pulmonary embolism
Prophylaxis in atrial fibrillation
Prevention of thromboembolic complications in prosthetic heart valves
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Nicoumalone

Tablet

Nicoumalone is an oral anticoagulant belonging to the coumarin class. It works by inhibiting vitamin K-dependent clotting factors, thereby preventing the formation of harmful blood clots in veins, arteries, and the heart.

Speciality Cardiology | Hematology | Internal Medicine
Tags Anticoagulant | Thrombosis Prevention | Oral Anticoagulant | Blood Clot Prevention
Strength
  • 1 mg
  • 2 mg
  • 3 mg
  • 4 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Nicoumalone inhibits vitamin K epoxide reductase, preventing activation of clotting factors II, VII, IX, and X. This reduces blood coagulation and prevents thrombus formation.

Pharmacokinetics

  • Absorption: Rapid oral absorption.
  • Distribution: Highly protein bound (~97%).
  • Metabolism: Hepatic metabolism.
  • Elimination: Excreted in urine and bile.
  • Half-life: ~20–30 hours.

Side Effects

  • Bleeding (major or minor)
  • Bruising
  • Nausea
  • Skin rashes
  • Rare: hepatic dysfunction

Contraindication

  • Hypersensitivity to Nicoumalone or coumarins
  • Pregnancy (teratogenic risk)
  • Active bleeding or bleeding disorders
  • Severe hepatic impairment

Interaction

  • Antibiotics: May enhance anticoagulant effect.
  • NSAIDs: Increased bleeding risk.
  • Other anticoagulants: Additive effect.
  • Vitamin K-rich foods: May reduce efficacy.

Warning and Precautions

  • Monitor INR regularly to adjust dosage.
  • Educate patients about bleeding risks.
  • Use cautiously in elderly patients.
  • Discontinue if severe bleeding occurs.

Dosage

As directed by the Physician.