Nicorandil Tablets

Therapeutic Indication

Stable angina (chest pain)

Adjunct therapy in ischemic heart disease

Alternative for patients intolerant to beta-blockers or calcium channel blockers

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Nicorandil

Tablet

Nicorandil is a vasodilator used in the management of angina pectoris. It combines potassium channel opening with nitrate-like activity, reducing both preload and afterload on the heart, thereby improving oxygen supply and decreasing chest pain episodes.

Speciality	Cardiology
Tags	Angina \| Heart Disease \| Vasodilator \| Antianginal
Strength	5 mg
Packing Size	10 Tablets

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Mechanism

Nicorandil opens potassium channels, causing arterial and venous dilation. It also has nitrate-like properties, releasing nitric oxide to relax vascular smooth muscle. This dual action reduces cardiac workload and improves coronary blood flow.

Pharmacokinetics

Absorption: Rapidly absorbed orally.
Distribution: Widely distributed in tissues.
Metabolism: Metabolized in the liver.
Elimination: Excreted mainly via urine.
Half-life: ~1–2 hours.

Side Effects

Headache
Dizziness
Flushing
Palpitations
Mouth ulcers
Gastrointestinal ulcers

Contraindication

Cardiogenic shock
Severe hypotension
Pregnancy and lactation
Children (not recommended)

Interaction

PDE5 inhibitors (sildenafil, tadalafil) – risk of severe hypotension
Alcohol – enhances blood pressure lowering effect
Other vasodilators – additive effect

Warning and Precautions

Use under medical supervision
Monitor blood pressure regularly
Risk of mouth and GI ulcers with prolonged use
Not recommended for smokers above 35 years
Regular cardiac check-up advised

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.